KMID : 0384620060170040252
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Korean Journal of Medical Physics 2006 Volume.17 No. 4 p.252 ~ p.259
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The Role of Gap Junction in the Goldfish¡¯s Motion Detection Measured with Optometer Response
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Lee Yung-Seb
Yoon Yung-Hyun Jung Chang-Sub
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Abstract
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Gap junctions are distributed within various cells and function as electrical synapses by freely exchanging small molecules. In the retina, the practical role of gap junctions in an animal¡¯¡¯s motion detection has not been investigated very much. In this study, optometer response (OMR) was used to Investigate the effects of drugs which modulate electrical synapses between retinal ceils. An Injection of carbenoxolone, 8-Br-cAMP, sodium nitroprusside (SNP) or 8-Br-cGMP decreased goldfish¡¯¡¯s OMR in both light and dark conditions. In light conditions, an intravitreal injection of dopamine, SKF-38393 or eticlopride decreased OMR and that of SCH-23390 increased it. In dark conditions, the injections produced opposite results: dopamine, SKF-38393 and eticlopride increased OMR and SCH-23390 caused OMR to decrease. These results indicate that gap junctions between retinal cells have an Important role in goldfish¡¯¡¯s motion detection.
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KEYWORD
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Motion detection, Gap junction, Horizontal cell, Dopamine, Nitric oxide
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